α-ketoglutaric (328-50-7) (71686-01-6) - Fabrîkaya çêker

α-ketoglutaric

Kapasîteya Cofftek heye ku di bin mercê cGMP de hilberîna girseyî û dabînkirina Acîdê Kalsiyûm 2-oxoglutarate û Alfa-Ketoglutaric Acid heye.

Acidê Alpha-Ketoglutaric (328-50-7) çi ye?

Aca Alpha-ketoglutaric pêkhateyek biyolojîkî ye ku bi xwezayî di laşê mirovan de tê dîtin. Di heman demê de wekî lêzêdekek parêz, acid-alpha-ketoglutaric di çerxa Krebs de (rêzeyek bertekên kîmyewî ku ji bo serbestberdana enerjiya depokirî tê bikar anîn) xwedî roleke sereke ye. Pêdivî ye ku pêvekên asîdên Alpha-ketoglutaric ji bo cûrbecûr sûdên tenduristiyê pêşkêşî bikin, di nav de performansa werzîşê ya xurtkirî û metabolîzma çêtirîn.

Alfa-Ketoglutaric Acid (328-50-7) sûd werdigire

Bi vê gotinê re, çend lêkolînên destpêkê li ser sûdên potansiyel ên lêzêdekirina asîdê alpha-ketoglutaric diyar kirin. Li vir tiştê ku hin ji lêkolînên heyî dibêjin:
IseNexweşiya Gurçikê ya Kronîk
Alpha-ketoglutaric acid has been used since the late-1990s to help break down and absorb protein in people on hemodialysis who require a low-protein diet. Recent evidence suggests that it may also delay the need for dialysis in people with advanced chronic kidney disease (CKD). According to a 2017 study in the journal PLoS One, researchers identified and followed 1,483 people with advanced CKD who used an alpha-ketoglutaric acid supplement called Ketosteril. The average duration of the follow-up was 1.57 years. Compared to a matched set of individuals who didn't take the supplement, those who did were less likely to require long-term dialysis. The benefits extended only to those who took more than 5.5 tablets per day, indicating the effects were dose-dependent. Despite the positive findings, it is unclear what role alpha-ketoglutaric acid played in comparison to the supplement's other active ingredients. Further research is needed.

. Tenduristiya Gastrointestinal
Alpha-ketoglutaric acid supplements are believed to be anticatabolic, meaning that it slows or prevents or catabolism (the breakdown of tissues). By definition, a catabolic process is opposite to an anabolic process (in which tissues are built). A 2012 study in the Italian Journal of Animal Science reported that alpha-ketoglutaric acid prevented the breakdown of the intestines in lab rats fed a protein-free diet for 14 days. Rather than experiencing damage to the finger-like villi of the intestines—the expected outcome—the rats fed alpha-ketoglutaric acid had no visible damage compared to rats that weren't. Moreover, the rats provided the supplements were able to maintain normal growth despite the total lack of protein. Higher doses conferred to even better results. The findings appear to support alpha-ketoglutaric acid's anticatabolic effects. In addition to its application in chronic kidney disease, alpha-ketoglutaric acid may also aid people with intestinal toxemia and malabsorption disorders like celiac disease. Further research is needed.

. Performansa Atletîk
By contrast, the anticatabolic effects of alpha-ketoglutaric acid appear to fall short when used for the purpose of muscle growth and athletic performance. According to a 2012 study in the Journal of the International Society of Sports Nutrition, alpha-ketoglutaric acid had no tangible effect on either muscle strength or exercise endurance in 16 men tasked with a resistance training workout. For this study, half of the men were given 3,000-milligrams (mg) of alpha-ketoglutaric acid, while the other half were given a placebo 45 minutes before doing bench press and leg press exercises. The following week, the supplements were flipped, with each half getting the alternate drug. Athletic performance was based on the total load volume (TLV) of the exercises performed in tandem with pre- and post-exercise heart rates. What these findings demonstrate is the absence of catabolic response is not the same thing as an anabolic response, especially among athletes.

Acîdê Alpha-Ketoglutaric (328-50-7) bikar tîne?

In heart surgery, alpha-ketoglutaric acid is sometimes delivered intravenously (into a vein) to reduce damage to the heart muscle due to the reduced blood flow. Doing so may also improve blood flow to the kidney following the surgery. Its use as a supplement is far less certain. Alternative practitioners believe that alpha-ketoglutaric acid can treat or prevent a wide variety of health conditions, including:
  • Cataracts
  • Nexweşiya gurî
  • Hepatomegaly (kezeba mezin)
  • Toxemiya rûvî
  • Xurpika devkî
  • Osteoporosis
  • Tendinopatî
  • Enfeksiyonên yeşî
Because of its role in releasing stored energy, alpha-ketoglutaric acid is often marketed as a sports performance supplement. Some proponents even assert that the supplement's antioxidant effects can slow aging. As is often the case with supplements that claim to treat multiple unrelated conditions, the evidence supporting these claims is weak. Some, like the supplement's "anti-aging" properties (based largely on a 2014 study involving nematode worms), border on the improbable.

Dermana Alfa-Ketoglutaric Acid (328-50-7)

Alpha-ketoglutaric acid supplements are available in tablet, capsule, and powder formulations and can be readily found online or in stores specializing in dietary supplements. There are no universal guidelines for the appropriate use of alpha-ketoglutaric acids. Supplements are typically sold in dosages ranging from 300 milligrams (mg) to 1,000 mg taken once daily with or without food. Doses of up to 3,000 mg have been used in studies with no adverse effects.

Alfa-Ketoglutaric Acid (328-50-7) tesîrên gengaz

Alpha-ketoglutaric acid is considered safe and well-tolerated. Studies investigating the effects of alpha-ketoglutaric acid reported few adverse symptoms after three years of use. As a compound made from non-essential amino acids, alpha-ketoglutaric acid is not a substance on which you can readily overdose. Any excess in the body will either be excreted in urine or broken down into the basic amino acid building blocks for other purposes. With that said, the safety of alpha-ketoglutaric acid in pregnant women, nursing mothers, and children has not been established. This includes children with rare metabolism disorders such as alpha-ketoglutarate dehydrogenase deficiency (in which alpha-ketoglutaric acid levels are abnormally elevated).

Powderê Acîdê Alpha-Ketoglutaric ji bo firotanê (Ku bi komê toza Alpha-Ketoglutaric Acid bikire)

Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. We also focus on value-added services. We are available for service questions and information to support your business. We are an professional Alpha-Ketoglutaric Acid powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

Balkêşî:

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  2. Alpers DH. Glutamine: gelo dane piştgirî didin sedema lêzêdekirina glutamîn li mirovan? Gastroenterolojî. 2006; 130: S106 – S116. doi: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Li pey birînê amîno asîdên masûlk û plasma. Ann Surg. 1980; 192: 78–85. doi: 10.1097 / 00000658-198007000-00014.